Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms14256
Abstract: Limiting the debilitating consequences of ageing is a major medical challenge of our time. Robust pharmacological interventions that promote healthy ageing across diverse genetic backgrounds may engage conserved longevity pathways. Here we report results from… read more here.
Keywords: experimental reproducibility; longevity; background experimental; genetic background ... See more keywords
Impact of genetic variants in clinical outcome of a cohort of patients with oropharyngeal squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-66741-z
Abstract: Tobacco- or human papillomavirus- driven oropharyngeal squamous cell carcinomas (OpSCC) represent distinct clinical, biological and epidemiological entities. The aim of this study was to identify genetic variants based on somatic alterations in OpSCC samples from… read more here.
Keywords: variants clinical; genetic variants; squamous cell; impact genetic ... See more keywords
Impact on genetic differences among various chicken breeds on free amino acid contents of egg yolk and albumen
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DOI: 10.1038/s41598-021-81660-3
Abstract: Eggs play important roles as food resources and nutraceuticals, to alleviate malnutrition and to improve health status in the world. Since free amino acids contribute to the nutritional values and food tastes, we investigated a… read more here.
Keywords: acid traits; amino acid; genetic differences; chicken breeds ... See more keywords
P180 The impact of genetic factors in kidney malformations in children
Sign Up to like & getrecommendations! Published in 2017 at "Archives of Disease in Childhood"
DOI: 10.1136/archdischild-2017-313273.268
Abstract: The incidence of congenital malformations of kidney and urinary tract pathology child is high, it represents a public health problem. Renal and urinary pathology in children ranks 3rd after respiratory and digestive pathology. Early diagnosis… read more here.
Keywords: renal failure; p180 impact; pathology; kidney malformations ... See more keywords
Abstract 14: The impact of genetic background on cancer phenotypes of mouse models
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-14
Abstract: The laboratory mouse is the premier animal model system for in vivo studies of the genetic and genomic basis of cancer in humans. Although thousands of mouse models have been generated, finding relevant data and… read more here.
Keywords: impact genetic; genetic background; mouse models; cancer ... See more keywords
Abstract PHB02: Impact of genetic diversity on the growth of human-derived xenografts
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.camodels2020-phb02
Abstract: The generation of human patient-derived xenograft (hPDX) models, and efficacy testing on human cell-derived xenografts (hCDX) or hPDX, are usually performed on a single mouse genetic background. Emerging evidence suggests that host genetic background underlies… read more here.
Keywords: genetic diversity; derived xenografts; human derived; impact genetic ... See more keywords
Novel Psychoactive Phenethylamines: Impact on Genetic Material
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DOI: 10.3390/ijms21249616
Abstract: Psychedelic and stimulating phenethylamines belong to the family of new psychoactive substances (NPS). The acute toxicity framework has begun to be investigated, while studies showing genotoxic potential are very limited or not available. Therefore, in… read more here.
Keywords: genetic material; psychoactive phenethylamines; phenethylamines impact; genotoxicity ... See more keywords