Identification of a G-Protein-Independent Activator of GIRK Channels.
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DOI: 10.1016/j.celrep.2020.107770
Abstract: G-protein-gated inwardly rectifying K+ (GIRK) channels are essential effectors of inhibitory neurotransmission in the brain. GIRK channels have been implicated in diseases with abnormal neuronal excitability, including epilepsy and addiction. GIRK channels are tetramers composed… read more here.
Keywords: identification protein; independent activator; protein independent; girk channels ... See more keywords
AMP-independent activator of AMPK for treatment of mitochondrial disorders
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DOI: 10.1371/journal.pone.0240517
Abstract: Mitochondrial diseases are a clinically heterogenous group of disorders caused by respiratory chain dysfunction and associated with progressive, multi-systemic phenotype. There is no effective treatment or cure, and no FDA-approved drug for treating mitochondrial disease.… read more here.
Keywords: independent activator; amp independent; treatment mitochondrial; treatment ... See more keywords