Bromodomain inhibition overcomes treatment resistance in distinct molecular subtypes of melanoma
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2206824119
Abstract: Significance Resistance to targeted and immunotherapeutic agents has emerged as a critical impediment to melanoma therapy. This study identifies the bromosporine/cobimetinib combination as a therapeutic strategy with broad-based activity in multiple settings, including in both… read more here.
Keywords: bromodomain inhibition; melanoma; inhibition overcomes; resistance ... See more keywords
SUMOylation inhibition overcomes proteasome inhibitor resistance in multiple myeloma
Sign Up to like & getrecommendations! Published in 2022 at "Blood Advances"
DOI: 10.1182/bloodadvances.2022007875
Abstract: Key Points • The SUMO pathway is activated in MM and its magnitude associated with progression and treatment resistance.• SUMO inhibition overcomes proteasome inhibitor resistance by blocking myeloma stress resilience, irrespective of p53 state. read more here.
Keywords: inhibitor resistance; overcomes proteasome; inhibition overcomes; proteasome inhibitor ... See more keywords