Insulin null ß-cells have a prohormone processing defect that is not reversed by AAV rescue of proinsulin expression.
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DOI: 10.1210/endocr/bqac051
Abstract: Up to 6% of diabetes has a monogenic cause including mutations in the insulin gene and patients are candidates for a gene therapy. Using a mouse model of permanent neonatal diabetes, we assessed the efficacy… read more here.
Keywords: ins1; processing defect; expression; proinsulin ... See more keywords