Isobavachalcone Attenuates MPTP-Induced Parkinson's Disease in Mice by Inhibition of Microglial Activation through NF-κB Pathway
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DOI: 10.1371/journal.pone.0169560
Abstract: Parkinson's disease (PD) is a complex multi-system and age-related neurodegenerative disorder. The intervention targeting neuroinflammation in PD patients is one effective strategy to slow down or inhibit disease progression. Microglia-mediated inflammatory response plays an important… read more here.
Keywords: isobavachalcone; disease; activation; mice ... See more keywords
Cocktail of isobavachalcone and curcumin enhance eradication of Staphylococcus aureus biofilm from orthopedic implants by gentamicin and alleviate inflammatory osteolysis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.958132
Abstract: Orthopedic device-related infection (ODRI) caused by Staphylococcus aureus, especially methicillin-resistant S. aureus (MRSA) biofilm may lead to persist infection and severe inflammatory osteolysis. Previous studies have demonstrated that both isobavachalcone and curcumin possess antimicrobial activity,… read more here.
Keywords: isobavachalcone; isobavachalcone curcumin; biofilm; aureus ... See more keywords
Heterologous biosynthesis of isobavachalcone in tobacco based on in planta screening of prenyltransferases
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DOI: 10.3389/fpls.2022.1034625
Abstract: Isobavachalcone (IBC) is a prenylated chalcone mainly distributed in some Fabaceae and Moraceae species. IBC exhibits a wide range of pharmacological properties, including anti-bacterial, anti-viral, anti-inflammatory, and anti-cancer activities. In this study, we attempted to… read more here.
Keywords: biosynthesis; sffpt; isobavachalcone; tobacco ... See more keywords
Isobavachalcone as an Active Membrane Perturbing Agent and Inhibitor of ABCB1 Multidrug Transporter
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DOI: 10.3390/molecules26154637
Abstract: Isobavachalcone (IBC) is an active substance from the medicinal plant Psoralea corylifolia. This prenylated chalcone was reported to possess antioxidative, anti-inflammatory, antibacterial, and anticancer activities. Multidrug resistance (MDR) associated with the over-expression of the transporters… read more here.
Keywords: mdr; isobavachalcone; membrane; inhibitor abcb1 ... See more keywords