Tandem Addition/Cyclization for Access to Isoquinolines and Isoquinolones via Catalytic Carbopalladation of Nitriles.
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DOI: 10.1021/acs.orglett.6b03499
Abstract: The first example of the palladium-catalyzed sequential nucleophilic addition followed by an intramolecular cyclization of functionalized nitriles with arylboronic acids has been achieved, providing an efficient synthetic pathway to access structurally diverse isoquinolines and isoquinolones.… read more here.
Keywords: isoquinolines isoquinolones; addition; tandem addition; addition cyclization ... See more keywords