Turn-engineering tunes the conformational rigidity of β-hairpin AMPs in achieving membrane selectivity and killing drug-resistant ESKAPE pathogens
Sign Up to like & getrecommendations! Published in 2025 at "Chemical Science"
DOI: 10.1039/d5sc06810j
Abstract: Naturally occurring β-hairpin antimicrobial peptides (AMPs) exhibit potent membranolytic activity against bacterial and mammalian cells, limiting their therapeutic development due to the lack of selectivity. This study demonstrates that the reverse turn in these AMPs… read more here.
Keywords: killing drug; turn; rigidity; selectivity ... See more keywords
Antibiotic killing of drug-induced bacteriostatic cells
Sign Up to like & getrecommendations! Published in 2025 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00156-25
Abstract: ABSTRACT There is a long-standing belief that bacteriostatic drugs are inherently antagonistic to the action of bactericidal antibiotics. This belief is primarily because the action of most bactericidal antibiotics requires the target bacteria to be… read more here.
Keywords: killing drug; induced bacteriostatic; drug induced; antibiotic killing ... See more keywords