The MBOAT7 rs641738 variant is associated with an improved outcome in primary sclerosing cholangitis.
Sign Up to like & getrecommendations! Published in 2020 at "Clinics and research in hepatology and gastroenterology"
DOI: 10.1016/j.clinre.2019.12.006
Abstract: BACKGROUND AND AIMS Primary sclerosing cholangitis (PSC) is a chronic cholestatic disease that causes liver cirrhosis, leading to liver failure. Additionally, PSC is a risk factor for cholangiocarcinoma. Its mechanism is unknown, and liver transplantation… read more here.
Keywords: cell line; mboat7 rs641738; primary sclerosing; mboat7 ... See more keywords
Could inherited predisposition drive non-obese fatty liver disease? Results from German tertiary referral centers
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DOI: 10.1038/s10038-018-0420-4
Abstract: Non-alcoholic fatty liver disease (NAFLD) is frequent among obese individuals with metabolic syndrome. Variants PNPLA3 p.I148M, TM6SF2 p.E167K and MBOAT7 rs641738 are associated with higher liver fat contents. Here we analyzed 63 biopsied non-obese, non-diabetic… read more here.
Keywords: non obese; liver disease; fatty liver; mboat7 ... See more keywords
Evaluation of Polygenic Determinants of Non-Alcoholic Fatty Liver Disease (NAFLD) By a Candidate Genes Resequencing Strategy
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DOI: 10.1038/s41598-018-21939-0
Abstract: NAFLD is a polygenic condition but the individual and cumulative contribution of identified genes remains to be established. To get additional insight into the genetic architecture of NAFLD, GWAS-identified GCKR, PPP1R3B, NCAN, LYPLAL1 and TM6SF2… read more here.
Keywords: alcoholic fatty; polygenic determinants; non alcoholic; evaluation polygenic ... See more keywords
Effects of MBOAT7 polymorphism and steatosis on liver function assessed by methacetin breath-test.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of clinical investigation"
DOI: 10.1111/eci.14003
Abstract: MBOAT7 rs641738 variant is a risk factor for nonalcoholic fatty liver disease (NAFLD) and liver fibrosis but the relationship between this polymorphism and early liver dysfunction remains uncertain. Eighty outpatients underwent blood analyses, liver imaging… read more here.
Keywords: liver; polymorphism; mboat7; steatosis ... See more keywords