Temozolomide sensitizes MGMT-deficient tumor cells to ATR inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer research"
DOI: 10.1158/0008-5472.can-18-3394
Abstract: O6-methylguanine-DNA methyltransferase (MGMT) is an enzyme that removes alkyl groups at the O6-position of guanine in DNA. MGMT expression is reduced or absent in many tumor types derived from a diverse range of tissues, most… read more here.
Keywords: dna; mgmt expression; tumor cells; atr inhibitors ... See more keywords
Alkylating agent rechallenge in metastatic pancreatic neuroendocrine tumours.
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DOI: 10.1530/erc-21-0034
Abstract: A rechallenge is common after initial efficacy of alkylating-based chemotherapy (ALK) in pancreatic neuroendocrine tumors (PanNET). High MGMT expression seems associated with lower response to ALK. We aimed to evaluate the efficacy and toxicity of… read more here.
Keywords: alk; mgmt expression; efficacy; alk rechallenge ... See more keywords
MicroRNA-142-3p is involved in regulation of MGMT expression in glioblastoma cells
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DOI: 10.2147/cmar.s157261
Abstract: Background Glioblastoma multiforme (GBM) is the most malignant brain tumor, and there is no effective treatment strategy. Patients with GBM have a median overall survival of only 14.6 months. Current treatment consists of safe and… read more here.
Keywords: glioblastoma; mgmt expression; gbm; mir 142 ... See more keywords
MGMT Expression Contributes to Temozolomide Resistance in H3K27M-Mutant Diffuse Midline Gliomas
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DOI: 10.3389/fonc.2019.01568
Abstract: Diffuse midline gliomas (DMGs) show resistance to many chemotherapeutic agents including temozolomide (TMZ). Histone gene mutations in DMGs trigger epigenetic changes including DNA hypomethylation, one of which is a frequent lack of O6-methyl-guanine-DNA methyltransferase (MGMT)… read more here.
Keywords: mgmt expression; diffuse midline; resistance; expression ... See more keywords