Mitochondrial tRNALeu(UUR) C3275T, tRNAGln T4363C and tRNALys A8343G mutations may be associated with PCOS and metabolic syndrome.
Sign Up to like & getrecommendations! Published in 2018 at "Gene"
DOI: 10.1016/j.gene.2017.11.049
Abstract: Polycystic ovary syndrome (PCOS) is a very prevalent endocrine disease affecting reproductive women. Clinically, patients with this disorder are more vulnerable to develop type 2 diabetes mellitus (T2DM), cardiovascular events, as well as metabolic syndrome… read more here.
Keywords: pcos; trnaleu uur; metabolic syndrome; mutation ... See more keywords
Germline mutations: many roles in leukemogenesis.
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DOI: 10.1097/moh.0000000000000596
Abstract: PURPOSE OF REVIEW The purpose of this review is to summarize the current understanding of germline mutations as they contribute to leukemia development and progression. We also discuss how these new insights may help improve… read more here.
Keywords: leukemia; germline; development; progression ... See more keywords
Spliceosomal-RNA Mutations May Drive Medulloblastoma and Other Cancers.
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DOI: 10.1158/2159-8290.cd-rw2019-160
Abstract: Hotspot mutations in U1 snRNA are associated with several cancers and cause aberrant splicing. read more here.
Keywords: spliceosomal rna; may drive; drive medulloblastoma; rna mutations ... See more keywords