Metabotropic glutamate receptors as targets for novel anxiolytics
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DOI: 10.1016/j.coph.2018.02.004
Abstract: HighlightsPositive correlation between mGlu5 receptor signaling and anxiety‐related symptoms.mGlu5 receptor NAMs reduce OCD‐like symptoms in preclinical studies.Activation of mGlu4 receptors abolishes chronic pain‐induced anxiety in mice.Therapeutic potential of mGlu receptor modulation for anxiety disorders. &NA;… read more here.
Keywords: targets novel; metabotropic glutamate; anxiety disorders; mglu ... See more keywords