Flotillin-mediated endocytosis and ALIX–syntenin-1–mediated exocytosis protect the cell membrane from damage caused by necroptosis
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DOI: 10.1126/scisignal.aaw3423
Abstract: Two independent trafficking pathways remove phosphorylated MLKL from the plasma membrane to avert necroptosis. Exit the necroptosis executioner In cells dying by necroptosis, the pseudokinase MLKL becomes phosphorylated and competent to rupture the plasma membrane.… read more here.
Keywords: flotillin; necroptosis; phosphorylated mlkl; membrane ... See more keywords