Usefulness of the placebo lead-in design for clinical trials with binary outcomes
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DOI: 10.1177/17407745221140048
Abstract: Background: In placebo-controlled clinical trials to develop new drugs for the treatment of psychiatric or neurological disorders, a high and sometimes greater-than-expected placebo response makes it difficult to show the superiority of an investigational drug… read more here.
Keywords: trials binary; lead design; placebo lead; clinical trials ... See more keywords