Cellular Proteostasis in Neurodegeneration
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-1334-z
Abstract: The term proteostasis reflects the fine-tuned balance of cellular protein levels, mediated through a vast network of biochemical pathways. This requires the regulated control of protein folding, post-translational modification, and protein degradation. Due to the… read more here.
Keywords: protein; cellular proteostasis; proteostasis; neurodegenerative diseases ... See more keywords
The Sigma-1 Receptor at the Crossroad of Proteostasis, Neurodegeneration, and Autophagy
Sign Up to like & getrecommendations! Published in 2020 at "Trends in Neurosciences"
DOI: 10.1016/j.tins.2019.12.002
Abstract: Neurodegenerative diseases are linked to dysfunctional proteostasis and disturbed autophagy. Here, we discuss how the sigma-1 receptor (Sig-1R) may act at the intersection of this interaction, as loss-of-function mutations of this unique chaperone are associated… read more here.
Keywords: crossroad proteostasis; proteostasis; sigma receptor; receptor crossroad ... See more keywords