Overexpression of Rad51 Predicts Poor Prognosis in Colorectal Cancer: Our Experience with 54 Patients
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DOI: 10.1371/journal.pone.0167868
Abstract: Background Aberrant Rad51 expression is implicated in the progression of human malignancies. However, the role of Rad51 in colorectal cancer (CRC) remains undefined. This study aimed to establish a relationship between Rad51 and clinicopathologic features… read more here.
Keywords: poor prognosis; colorectal cancer; tissue; rad51 expression ... See more keywords
RAD51-Mediated DNA Homologous Recombination Is Independent of PTEN Mutational Status
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DOI: 10.3390/cancers12113178
Abstract: Simple Summary PTEN is an important tumor suppressor that is frequently mutated in malignancy. PTEN mutational loss has been associated with reduced RAD51 expression and homologous recombination deficiency (HRD), however; recent studies have failed to… read more here.
Keywords: activity; expression; pten deficient; rad51 expression ... See more keywords
PTEN Loss Enhances Error-Prone DSB Processing and Tumor Cell Radiosensitivity by Suppressing RAD51 Expression and Homologous Recombination
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DOI: 10.3390/ijms232112876
Abstract: PTEN has been implicated in the repair of DNA double-strand breaks (DSBs), particularly through homologous recombination (HR). However, other data fail to demonstrate a direct role of PTEN in DSB repair. Therefore, here, we report… read more here.
Keywords: rad51 expression; cell; dsb repair; repair ... See more keywords
Clinicopathological and Prognostic Characteristics of RAD51 in Colorectal Cancer
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DOI: 10.3390/medicina56020048
Abstract: Background and Objectives: RAD51 plays an essential role in DNA repair via homologous recombination. RAD51 facilitates strand transfer between interrupted sequences and their undamaged homologies. Therefore, we studied the RAD51 mRNA expression levels in colorectal… read more here.
Keywords: clinicopathological prognostic; colorectal cancer; expression; rad51 expression ... See more keywords