The Sigma-1 Receptor at the Crossroad of Proteostasis, Neurodegeneration, and Autophagy
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DOI: 10.1016/j.tins.2019.12.002
Abstract: Neurodegenerative diseases are linked to dysfunctional proteostasis and disturbed autophagy. Here, we discuss how the sigma-1 receptor (Sig-1R) may act at the intersection of this interaction, as loss-of-function mutations of this unique chaperone are associated… read more here.
Keywords: crossroad proteostasis; proteostasis; sigma receptor; receptor crossroad ... See more keywords
Toll-Like Receptor 2 at the Crossroad between Cancer Cells, the Immune System, and the Microbiota
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DOI: 10.3390/ijms21249418
Abstract: Toll-like receptor 2 (TLR2) expressed on myeloid cells mediates the recognition of harmful molecules belonging to invading pathogens or host damaged tissues, leading to inflammation. For this ability to activate immune responses, TLR2 has been… read more here.
Keywords: toll like; receptor crossroad; like receptor; cancer cells ... See more keywords