DFG-1 Binding: A New Residue for Developing Selective Kinase Inhibitors.
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DOI: 10.1021/acs.jmedchem.0c01501
Abstract: Only 15% of human kinases carry a bulky residue at the DFG-1 position, providing an opportunity for the design of selective ATP-site inhibitors without the typical hinge-binding interactions. The low sequence homology among unrelated kinases… read more here.
Keywords: dfg binding; kinase; binding new; new residue ... See more keywords