Mechanisms of artemisinin resistance in Plasmodium falciparum malaria
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in pharmacology"
DOI: 10.1016/j.coph.2018.06.003
Abstract: &NA; Artemisinin‐based combination therapies (ACTs) have substantially reduced worldwide malaria burden and deaths. But malaria parasites have become resistant to artemisinins. Prior studies suggested two different molecular pathways of artemisinin‐resistance. Here we unify recent findings… read more here.
Keywords: malaria; resistance plasmodium; mechanisms artemisinin; artemisinin resistance ... See more keywords
In Vitro Confirmation of Artemisinin Resistance in Plasmodium falciparum from Patient Isolates, Southern Rwanda, 2019
Sign Up to like & getrecommendations! Published in 2022 at "Emerging Infectious Diseases"
DOI: 10.3201/eid2804.212269
Abstract: Artemisinin resistance in Plasmodium falciparum is conferred by mutations in the kelch 13 (K13) gene. In Rwanda, K13 mutations have increased over the past decade, including mutations associated with delayed parasite clearance. We document artemisinin… read more here.
Keywords: artemisinin; plasmodium falciparum; resistance plasmodium; artemisinin resistance ... See more keywords
Molecular Detection of Antimalarial Drug Resistance in Plasmodium vivax from Returned Travellers to NSW, Australia during 2008–2018
Sign Up to like & getrecommendations! Published in 2020 at "Pathogens"
DOI: 10.3390/pathogens9020101
Abstract: To monitor drug resistance in Plasmodium vivax, a multidrug resistance 1 (Pvmdr1) gene and a putative transporter protein (Pvcrt-o) gene were used as molecular markers for chloroquine resistance. The biomarkers, the dihydrofolate reductase (Pvdhfr) gene… read more here.
Keywords: drug resistance; resistance plasmodium; vivax; resistance ... See more keywords