Structural Model for Recruitment of RIT1 to the LZTR1 E3 Ligase: Evidences from an Integrated Computational Approach
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Chemical Information and Modeling"
DOI: 10.1021/acs.jcim.1c00296
Abstract: Leucine-zipper transcription regulator 1 (LZTR1) is a highly mutated tumor suppressor gene, involved in the pathogenesis of several cancer types and developmental disorders. In proteasomal degradation, it acts as an adaptor protein responsible for the… read more here.
Keywords: protein; computational approach; recruitment; integrated computational ... See more keywords
IGF-1 mediated Neurogenesis Involves a Novel RIT1/Akt/Sox2 Cascade
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DOI: 10.1038/s41598-017-03641-9
Abstract: Insulin-like growth factor 1 (IGF-1) is known to have diverse effects on brain structure and function, including the promotion of stem cell proliferation and neurogenesis in the adult dentate gyrus. However, the intracellular pathways downstream… read more here.
Keywords: neurogenesis; igf; sox2; rit1 akt ... See more keywords
Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs
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DOI: 10.1101/2022.01.04.474894
Abstract: RAS GTPases are highly conserved proteins involved in the regulation of mitogenic signaling. We have previously described a novel Cullin 3 RING E3 ubiquitin ligase complex formed by the substrate adaptor protein LZTR1 that binds,… read more here.
Keywords: lztr1 loss; loss function; rit1 orthologs; dependency rit1 ... See more keywords
Abstract B028: Pharmacological inhibition of USP9X as a novel targeted therapy for RIT1-driven lung adenocarcinoma and other cancers
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.ras23-b028
Abstract: Since its discovery as an oncogene in 2014, mutations and amplifications in the small GTPase RIT1 (Ras-like in all tissues) have been associated with lung adenocarcinoma, myeloid malignancies, and uterine carcinosarcoma. Genome-sequencing studies in lung… read more here.
Keywords: rit1; rit1 driven; inhibition; lung adenocarcinoma ... See more keywords