Capturing the photo‐signaling state of a photoreceptor in a steady‐state fashion by binding a transition metal complex
Sign Up to like & getrecommendations! Published in 2017 at "Protein Science"
DOI: 10.1002/pro.3284
Abstract: Binding a small molecule to proteins causes conformational changes, but often to a limited extent. Here, we demonstrate that the interaction of a CO‐releasing molecule (CORM3) with a photoreceptor photoactive yellow protein (PYP) drives large… read more here.
Keywords: state; protein; signaling state; photoreceptor ... See more keywords
When More Is Less: Dual Phosphorylation Protects Signaling Off State against Overexpression.
Sign Up to like & getrecommendations! Published in 2018 at "Biophysical journal"
DOI: 10.1016/j.bpj.2018.08.019
Abstract: Kinases in signaling pathways are commonly activated by multisite phosphorylation. For example, the mitogen-activated protein kinase Erk is activated by its kinase Mek by two consecutive phosphorylations within its activation loop. In this article, we… read more here.
Keywords: signaling state; increasing amounts; protects signaling; amounts erk ... See more keywords