Internalized SNCA/α-synuclein fibrils become truncated and resist degradation in neurons while glial cells rapidly degrade SNCA fibrils.
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DOI: 10.1080/15548627.2025.2579147
Abstract: ABSTRACT Parkinson disease (PD) and other α-synucleinopathies are characterized by the intracellular aggregates of SNCA/α-synuclein (synuclein, alpha) thought to spread via cell-to-cell transmission. To understand the contributions of various brain cells to the spreading of… read more here.
Keywords: snca aggregates; snca fibrils; snca synuclein; internalized snca ... See more keywords