SPRED2 deficiency elicits cardiac arrhythmias and premature death via impaired autophagy.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2019.01.023
Abstract: Cardiac functionality is dependent on a balanced protein turnover. Accordingly, regulated protein decay is critical to maintain cardiac function. Here we demonstrate that deficiency of SPRED2, an intracellular repressor of ERK-MAPK signaling markedly expressed in… read more here.
Keywords: spred2 deficiency; spred2; impaired autophagy; deficiency elicits ... See more keywords
microRNA-141-3p mediates epithelial cell proliferation, apoptosis, and epithelial-mesenchymal transition and alleviates pulmonary fibrosis in mice via Spred2.
Sign Up to like & getrecommendations! Published in 2023 at "Histology and histopathology"
DOI: 10.14670/hh-18-585
Abstract: OBJECTIVE This study probed the mechanism of microRNA (miR)-141-3p in the progression of pulmonary fibrosis (PF). METHODS Mice were intratracheally administered with bleomycin (BLM) to establish a PF mouse model. To investigate the effects of… read more here.
Keywords: apoptosis; proliferation; pulmonary fibrosis; mir 141 ... See more keywords
Hyperactivation of MAPK Induces Tamoxifen Resistance in SPRED2-Deficient ERĪ±-Positive Breast Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14040954
Abstract: Simple Summary Tamoxifen has been used for more than 40 years to treat breast tumors that are dependent on the hormone estrogen for their growth. However, resistance and recurrence of the tumors during the course… read more here.
Keywords: breast; breast cancer; tamoxifen resistance; spred2 ... See more keywords