From proteomics to discovery of first-in-class ST2 inhibitors active in vivo.
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DOI: 10.1172/jci.insight.99208
Abstract: Soluble cytokine receptors function as decoy receptors to attenuate cytokine-mediated signaling and modulate downstream cellular responses. Dysregulated overproduction of soluble receptors can be pathological, such as soluble ST2 (sST2), a prognostic biomarker in cardiovascular diseases,… read more here.
Keywords: vivo; st2 inhibitors; discovery first; proteomics discovery ... See more keywords