Mechanisms of typhoid toxin neutralization by antibodies targeting glycan receptor binding and nuclease subunits
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DOI: 10.1016/j.isci.2021.102454
Abstract: Summary Nearly all clinical isolates of Salmonella Typhi, the cause of typhoid fever, are antibiotic resistant. All S. Typhi isolates secrete an A2B5 exotoxin called typhoid toxin to benefit the pathogen during infection. Here, we… read more here.
Keywords: targeting glycan; glycan receptor; toxin; antibodies targeting ... See more keywords
Recent Progress in Clinical Development of Therapeutic Antibodies Targeting Glycan-Binding Proteins.
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DOI: 10.2174/1389450119666180308144313
Abstract: BACKGROUND Glycan-binding proteins are widely distributed in human and play an essential role in biological processes. Their involvements in inflammatory and immune responses make it increasingly likely that the glycan-binding proteins may represent valuable therapeutic… read more here.
Keywords: glycan binding; therapeutic antibodies; targeting glycan; binding proteins ... See more keywords