TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS
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DOI: 10.1016/j.cell.2020.09.020
Abstract: Summary Cytoplasmic accumulation of TDP-43 is a disease hallmark for many cases of amyotrophic lateral sclerosis (ALS), associated with a neuroinflammatory cytokine profile related to upregulation of nuclear factor κB (NF-κB) and type I interferon… read more here.
Keywords: cgas; tdp triggers; dna; triggers mitochondrial ... See more keywords