How does early‐life adversity shape telomere dynamics during adulthood? Problems and paradigms
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DOI: 10.1002/bies.202100184
Abstract: Although early‐life adversity has been associated with negative consequences during adulthood, growing evidence shows that such adversity can also lead to subsequent stress resilience and positive fitness outcomes. Telomere dynamics are relevant in this context… read more here.
Keywords: early life; life adversity; telomere dynamics; adult telomere ... See more keywords
Sex-Specific Associations between Telomere Dynamics and Oxidative Status in Adult and Nestling Pied Flycatchers
Sign Up to like & getrecommendations! Published in 2018 at "Physiological and Biochemical Zoology"
DOI: 10.1086/697294
Abstract: Oxidative stress can contribute to an acceleration of telomere erosion, leading to cellular senescence and aging. Increased investment in reproduction is known to accelerate senescence, generally resulting in reduced future reproductive potential and survival. To… read more here.
Keywords: status; oxidative status; telomere dynamics; specific associations ... See more keywords
Molecular Mechanism of Telomere Length Dynamics and Its Prognostic Value in Pediatric Cancers.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the National Cancer Institute"
DOI: 10.1093/jnci/djz210
Abstract: BACKGROUND We aimed to systematically evaluate telomere dynamics across a spectrum of pediatric cancers, search for underlying molecular mechanisms, and assess potential prognostic value. METHODS The fraction of telomeric reads was determined from whole-genome sequencing… read more here.
Keywords: telomere fractions; prognostic value; pediatric cancers; cancer ... See more keywords
RELATION BETWEEN TELOMERE DYNAMICS AND METABOLIC DISORDERS IN EARLY AGE
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DOI: 10.1097/01.hjh.0000838276.13779.83
Abstract: Objective: In adults, short leukocyte telomere length (LTL) is associated with metabolic disorders such as diabetes and obesity. The causality remains unclear since longitudinal studies do not show influence of metabolic disorders on LTL attrition.… read more here.
Keywords: ltl attrition; telomere dynamics; age; score ... See more keywords
Somatic growth and telomere dynamics in vertebrates: relationships, mechanisms and consequences
Sign Up to like & getrecommendations! Published in 2018 at "Philosophical Transactions of the Royal Society B: Biological Sciences"
DOI: 10.1098/rstb.2016.0446
Abstract: Much telomere loss takes place during the period of most rapid growth when cell proliferation and potentially energy expenditure are high. Fast growth is linked to reduced longevity. Therefore, the effects of somatic cell proliferation… read more here.
Keywords: somatic growth; growth telomere; telomere loss; dynamics vertebrates ... See more keywords
Telomere length in relation to colour polymorphism across life stages in the tawny owl
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Avian Biology"
DOI: 10.1111/jav.02564
Abstract: Telomere erosion has been proposed to be tightly associated with senescence, environmental stressors and life history trade-offs. How telomere dynamics vary across life stages and especially in relation to (heritable) phenotypic traits is still unclear.… read more here.
Keywords: morph specific; tawny owl; morph; life ... See more keywords
Drivers of longitudinal telomere dynamics in the long-lived bat species, Myotis myotis.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular ecology"
DOI: 10.1111/mec.15395
Abstract: Age related telomere shortening is considered a hallmark of the ageing process. However, a recent cross-sectional ageing study of relative telomere length (rTL) in bats failed to detect a relationship between rTL and age in… read more here.
Keywords: myotis myotis; myotis; rtl; age ... See more keywords
How telomere dynamics are influenced by the balance between mitochondrial efficiency, ROS production and DNA damage.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular ecology"
DOI: 10.1111/mec.16150
Abstract: It is well known that oxidative stress is a major cause of DNA damage and telomere attrition. Most endogenous Reactive Oxygen Species (ROS) are produced in the mitochondria, producing a link between mitochondrial function, DNA… read more here.
Keywords: production; dna; ros production; damage ... See more keywords
Monitoring of telomere dynamics in peripheral blood leukocytes in relation to colorectal cancer patients’ outcomes
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.962929
Abstract: We investigated the possible associations between leukocyte telomere length, therapy outcomes, and clinicopathological features in patients with colorectal cancer. Additionally, telomerase reverse transcriptase (TERT) expression was evaluated. Telomere length was measured using singleplex qPCR in… read more here.
Keywords: monitoring telomere; telomere length; diagnosis; telomere dynamics ... See more keywords