Overcoming resistance to cisplatin by inhibition of glutathione S-transferases (GSTs) with ethacraplatin micelles in vitro and in vivo.
Sign Up to like & getrecommendations! Published in 2017 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2017.08.021
Abstract: Platinum-based DNA-adducting agents are used extensively in the clinic for cancer chemotherapy. However, the anti-tumor efficacy of these drugs is severely limited by cisplatin resistance, and this can lead to the failure of chemotherapy. One… read more here.
Keywords: vitro vivo; overcoming resistance; cisplatin; resistance ... See more keywords
The role of glutathione S-transferases (GSTs) in insecticide resistance in crop pests and disease vectors.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in insect science"
DOI: 10.1016/j.cois.2018.04.007
Abstract: Insecticide resistance seriously threatens efficient arthropod pest management. Arthropod glutathione S-transferases (GSTs) confer resistance via direct metabolism or sequestration of chemicals, but also indirectly by providing protection against oxidative stress induced by insecticide exposure. To… read more here.
Keywords: resistance; role; glutathione transferases; insecticide resistance ... See more keywords