Reversing epigenetic repression of transposable elements for improving tumor immunogenicity
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Communications"
DOI: 10.1002/cac2.12261
Abstract: In a recent study published in Nature, Zhang et al. [1] revealed a new epigenetic mechanism for restraining tumor intrinsic immunogenicity: Lysine demethylase 5B (KDM5B) recruits SET domain bifurcated histone lysine methyltransferase 1 (SETDB1) to… read more here.
Keywords: transposable elements; repression; immunogenicity; reversing epigenetic ... See more keywords
Convergent Identification and Interrogation of Tumor-Intrinsic Factors that Modulate Cancer Immunity In Vivo.
Sign Up to like & getrecommendations! Published in 2019 at "Cell systems"
DOI: 10.1016/j.cels.2019.01.004
Abstract: The genetic makeup of cancer cells directs oncogenesis and influences the tumor microenvironment. In this study, we massively profiled genes that functionally drive tumorigenesis using genome-scale in vivo CRISPR screens in hosts with different levels of… read more here.
Keywords: convergent identification; interrogation; cancer; tumor microenvironment ... See more keywords
M2 macrophage-derived exosomes suppress tumor intrinsic immunogenicity to confer immunotherapy resistance
Sign Up to like & getrecommendations! Published in 2023 at "Oncoimmunology"
DOI: 10.1080/2162402x.2023.2210959
Abstract: ABSTRACT T-cell-based immune checkpoint blockade therapy (ICB) can be undermined by local immunosuppressive M2-like tumor-associated macrophages (TAMs). However, modulating macrophages has proved difficult as the molecular and functional features of M2-TAMs on tumor growth are… read more here.
Keywords: macrophage derived; resistance; tumor intrinsic; intrinsic immunogenicity ... See more keywords
Integrating Tumor-Intrinsic and Immunologic Factors to Identify Immunogenic Breast Cancers from a Low-Risk Cohort: Results from the Randomized SweBCG91RT Trial
Sign Up to like & getrecommendations! Published in 2023 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-22-2746
Abstract: Abstract Purpose: The local immune infiltrate's influence on tumor progression may be closely linked to tumor-intrinsic factors. The study aimed to investigate whether integrating immunologic and tumor-intrinsic factors can identify patients from a low-risk cohort… read more here.
Keywords: immune infiltrate; breast; factors identify; risk ... See more keywords
Abstract 2363: Ovarian tumor-intrinsic FAK-dependent regulation of the matrisome
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2363
Abstract: High-grade serous ovarian cancer (HGSOC) is deadliest of gynecological malignancies. Ovarian tumor cells can directly spread throughout the peritoneal space as single cells that grow into tumorspheres concomitant with the generation of malignant ascites that… read more here.
Keywords: fak; expression; ovarian tumor; intrinsic fak ... See more keywords
BCG-Induced Tumor Immunity Requires Tumor-Intrinsic CIITA Independent of MHC-II.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer immunology research"
DOI: 10.1158/2326-6066.cir-22-0157
Abstract: For decades, BCG immunotherapy has been the standard of care for non-muscle-invasive bladder cancer. Despite this clinical experience, the mechanism by which BCG stimulates tumor-eliminating immunity is unclear, and there is still a need for… read more here.
Keywords: cell; tumor immunity; ciita; immunity ... See more keywords
Resistance to PD-L1/PD-1 Blockade Immunotherapy. A Tumor-Intrinsic or Tumor-Extrinsic Phenomenon?
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.00441
Abstract: Cancer immunotherapies targeting immune checkpoints such as programmed cell-death protein 1 (PD-1) and its ligand programmed cell-death 1 ligand 1 (PD-L1), are revolutionizing cancer treatment and transforming the practice of medical oncology. However, despite all… read more here.
Keywords: blockade immunotherapy; resistance blockade; resistance; oncology ... See more keywords