Understanding and exploiting interactions between cellular proteostasis pathways and infectious prion proteins for therapeutic benefit
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DOI: 10.1098/rsob.200282
Abstract: Several neurodegenerative diseases of humans and animals are caused by the misfolded prion protein (PrPSc), a self-propagating protein infectious agent that aggregates into oligomeric, fibrillar structures and leads to cell death by incompletely understood mechanisms.… read more here.
Keywords: cellular proteostasis; interactions cellular; exploiting interactions; prion ... See more keywords