A validated chiral chromatographic method for the enantiomeric separation of acalabrutinib.
Sign Up to like & getrecommendations! Published in 2022 at "Chirality"
DOI: 10.1002/chir.23485
Abstract: Acalabrutinib is aided in the treatment of various cancers, which acts by inhibiting Bruton tyrosine kinase. Acalabrutinib belongs to the imidazopyrazine class consisting of a chiral carbon, resulting in two enantiomers. Currently, no methods exist… read more here.
Keywords: validated chiral; acalabrutinib; chromatographic method; chiral chromatographic ... See more keywords
A validated chiral LC method for the enantiomeric separation of AT13148 on polysaccharide-based chiral stationary phase
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the Iranian Chemical Society"
DOI: 10.1007/s13738-017-1270-2
Abstract: AbstractA sensitive and accurate LC method for the determination of AT13148 enantiomeric purity has been developed and validated. Baseline separation with a resolution higher than 1.8 was accomplished within 15 min using a Chiralpak AD-H column… read more here.
Keywords: phase; method; chiral method; at13148 ... See more keywords