Quantitative drug release monitoring in tumors of living subjects by magnetic particle imaging nanocomposite.
Sign Up to like & getrecommendations! Published in 2019 at "Nano letters"
DOI: 10.1021/acs.nanolett.9b01202
Abstract: In vivo drug release monitoring provides accurate and reliable information to guide drug dosing. Image-based strategies for in vivo monitoring are advantageous because they are non-invasive and provide visualization of the spatial distribution of drug,… read more here.
Keywords: drug; drug release; release monitoring; vivo drug ... See more keywords
Analyzing 2000 in Vivo Drug Delivery Data Points Reveals Cholesterol Structure Impacts Nanoparticle Delivery.
Sign Up to like & getrecommendations! Published in 2018 at "ACS nano"
DOI: 10.1021/acsnano.8b03640
Abstract: Lipid nanoparticles (LNPs) are formulated using unmodified cholesterol. However, cholesterol is naturally esterified and oxidized in vivo, and these cholesterol variants are differentially trafficked in vivo via lipoproteins including LDL and VLDL. We hypothesized that… read more here.
Keywords: delivery; cholesterol; analyzing 2000; vivo drug ... See more keywords
Inferring tumor-specific cancer dependencies through integrating ex vivo drug response assays and drug-protein profiling
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Computational Biology"
DOI: 10.1101/2022.01.11.475864
Abstract: The development of cancer therapies may be improved by the discovery of tumor-specific molecular dependencies. The requisite tools include genetic and chemical perturbations, each with its strengths and limitations. Drug perturbations can be readily applied… read more here.
Keywords: tumor specific; drug response; molecular dependencies; drug ... See more keywords
Abstract 3883: Gene expression predicts ex vivo drug sensitivity in acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-3883
Abstract: Introduction: Ex vivo drug sensitivity studies of samples derived from acute myeloid leukemia (AML) patients have been shown to be predictive of in vivo response. These findings are based on a limited number of well-characterized… read more here.
Keywords: response; drug; expression; drug sensitivity ... See more keywords
PDX-derived organoids model in vivo drug response and secrete biomarkers
Sign Up to like & getrecommendations! Published in 2020 at "JCI Insight"
DOI: 10.1172/jci.insight.135544
Abstract: Patient-derived organoid models are proving to be a powerful platform for both basic and translational studies. Here we conduct a methodical analysis of pancreatic ductal adenocarcinoma (PDAC) tumor organoid drug response in paired patient-derived xenograft… read more here.
Keywords: response; pdx derived; drug response; drug ... See more keywords
Ex vivo drug screening defines novel drug sensitivity patterns for informing personalized therapy in myeloid neoplasms.
Sign Up to like & getrecommendations! Published in 2020 at "Blood advances"
DOI: 10.1182/bloodadvances.2020001934
Abstract: Precision medicine approaches such as ex vivo drug sensitivity screening (DSS) are appealing to inform rational drug selection in myelodysplastic syndromes (MDSs) and acute myeloid leukemia, given their marked biologic heterogeneity. We evaluated a novel,… read more here.
Keywords: myeloid neoplasms; sensitivity patterns; drug; sensitivity ... See more keywords
In vivo drug delivery applications of nanogels: a review.
Sign Up to like & getrecommendations! Published in 2020 at "Nanomedicine"
DOI: 10.2217/nnm-2020-0274
Abstract: In recent years, nanogels have emerged as promising drug delivery vehicles; their ability in holding active molecules, macromolecules and drugs, together with the capability to respond to external stimuli, makes them a suitable tool for… read more here.
Keywords: delivery applications; drug delivery; drug; applications nanogels ... See more keywords
Ex Vivo Drug Sensitivity Correlates with Clinical Response and Supports Personalized Therapy in Pediatric AML
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14246240
Abstract: Simple Summary Children with acute myeloid leukemia (AML) experience unacceptably poor survival outcomes and are at high risk of relapse. Current treatment options are limited, and standard strategies rely on intensive chemotherapy to achieve remission,… read more here.
Keywords: sensitivity; sensitivity correlates; drug sensitivity; response ... See more keywords
Application of multiplexed pharmacokinetic immunoassay to quantify in vivo drug forms and coadministered biologics.
Sign Up to like & getrecommendations! Published in 2019 at "Bioanalysis"
DOI: 10.4155/bio-2019-0147
Abstract: Aim: Meso Scale Discovery U-PLEX® provides an opportunity to develop multiplexed pharmacokinetic (PK) immunoassays. Two case studies demonstrate the utility of multiplexed PK methods. Materials & methods: Development of PK ligand-binding assays quantify of nonclinical… read more here.
Keywords: multiplexed pharmacokinetic; pharmacokinetic immunoassay; application multiplexed; quantify vivo ... See more keywords