Distinct Temporal Structure of Nicotinic ACh Receptor Activation Determines Responses of VTA Neurons to Endogenous ACh and Nicotine
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DOI: 10.1523/eneuro.0418-19.2020
Abstract: Abstract The addictive component of tobacco, nicotine, acts via nicotinic acetylcholine receptors (nAChRs). The β2 subunit-containing nAChRs (β2-nAChRs) play a crucial role in the rewarding properties of nicotine and are particularly densely expressed in the… read more here.
Keywords: distinct temporal; ach nicotine; vta neurons; vta gaba ... See more keywords
β2 nAChR Activation on VTA DA Neurons Is Sufficient for Nicotine Reinforcement in Rats
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DOI: 10.1523/eneuro.0449-22.2023
Abstract: Abstract Mesolimbic nicotinic acetylcholine receptor (nAChRs) activation is necessary for nicotine reinforcement behavior, but it is unknown whether selective activation of nAChRs in the dopamine (DA) reward pathway is sufficient to support nicotine reinforcement. In… read more here.
Keywords: 2leu9 ser; activation; vta neurons; nicotine reinforcement ... See more keywords