Association of MAPT Subhaplotypes With Risk of Progressive Supranuclear Palsy and Severity of Tau Pathology.
Sign Up to like & getrecommendations! Published in 2019 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2019.0250
Abstract: Importance The association between the microtubule-associated protein tau (MAPT) H1 haplotype and the risk of progressive supranuclear palsy (PSP) has been well documented. However, the specific H1 subhaplotypes that drive the association have not been… read more here.
Keywords: risk; psp; tau pathology; pathology ... See more keywords
Association of MAPT subhaplotypes with clinical and demographic features in Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51139
Abstract: To determine whether distinct microtubule‐associated protein tau MAPT H1 subhaplotypes are associated with clinical and demographic features in Parkinson’s disease. read more here.
Keywords: mapt subhaplotypes; demographic features; features parkinson; clinical demographic ... See more keywords
In vivo evidence for pre‐symptomatic neuroinflammation in a MAPT mutation carrier
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.683
Abstract: Neuroinflammation occurs in frontotemporal dementia, however its timing relative to protein aggregation and neuronal loss is unknown. Using positron emission tomography and magnetic resonance imaging to quantify these processes in a pre‐symptomatic carrier of the… read more here.
Keywords: neuroinflammation; carrier; pre symptomatic; mapt mutation ... See more keywords
Ameliorating Mitochondrial Dysfunction of Neurons by Biomimetic Targeting Nanoparticles Mediated Mitochondrial Biogenesis to Boost the Therapy of Parkinson's Disease.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202300758
Abstract: Mitochondrial dysfunction of neurons is the core pathogenesis of incurable Parkinson's disease (PD). It is crucial to ameliorate the mitochondrial dysfunction of neurons for boosting the therapy of PD. Herein, the remarkable promotion of mitochondrial… read more here.
Keywords: mitochondrial biogenesis; parkinson disease; dysfunction neurons; mitochondrial dysfunction ... See more keywords
Presymptomatic spinal cord pathology in c9orf72 mutation carriers: A longitudinal neuroimaging study
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Neurology"
DOI: 10.1002/ana.25520
Abstract: C9orf72 hexanucleotide repeats expansions account for almost half of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) cases. Recent imaging studies in asymptomatic C9orf72 carriers have demonstrated cerebral white (WM) and gray matter (GM)… read more here.
Keywords: presymptomatic spinal; study; pathology; c9orf72 ... See more keywords
Dysregulation of the Retromer Complex System in Down Syndrome
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Neurology"
DOI: 10.1002/ana.25752
Abstract: Most of the patients with Down syndrome (DS) develop Alzheimer's disease (AD) neuropathology by age 40. Although this increased susceptibility to AD in DS is thought to be primarily due to triplication of the amyloid… read more here.
Keywords: dysregulation retromer; retromer complex; complex system;
Geometry‐derived statistical significance: A probabilistic framework for detecting true positive findings in MRI data
Sign Up to like & getrecommendations! Published in 2023 at "Brain and Behavior"
DOI: 10.1002/brb3.2865
Abstract: The false discovery rate (FDR) procedure does not incorporate the geometry of the random field and requires high statistical power at each voxel, a requirement not satisfied by the limited number of participants in imaging… read more here.
Keywords: statistical significance; probabilistic framework; geometry; significance probabilistic ... See more keywords
Yeast surface display of full‐length human microtubule‐associated protein tau
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology Progress"
DOI: 10.1002/btpr.2920
Abstract: Microtubule‐associated protein tau is an intrinsically disordered, highly soluble protein found primarily in neurons. Under normal conditions, tau regulates the stability of axonal microtubules and intracellular vesicle transport. However, in patients of neurodegeneration such as… read more here.
Keywords: protein; associated protein; tau; microtubule associated ... See more keywords
Corrigendum: A Fusion Method to Develop an Expanded Artificial Genomic RNA Replicable by Qβ Replicase
Sign Up to like & getrecommendations! Published in 2019 at "ChemBioChem"
DOI: 10.1002/cbic.201900617
Abstract: One or two additional mutations, which were not included in the analysis, were found in seven RNAs (G2168U in #5, G284U and C2462A in #7, C1253A and C1879A in #8, C2016A in #9, C1327U in… read more here.
Keywords: method develop; fusion method; corrigendum fusion; artificial genomic ... See more keywords
Sexual dimorphism in the inflammatory response to traumatic brain injury
Sign Up to like & getrecommendations! Published in 2017 at "Glia"
DOI: 10.1002/glia.23171
Abstract: The activation of resident microglial cells, alongside the infiltration of peripheral macrophages, are key neuroinflammatory responses to traumatic brain injury (TBI) that are directly associated with neuronal death. Sexual disparities in response to TBI have… read more here.
Keywords: traumatic brain; response; tbi; brain injury ... See more keywords
Longitudinal brain atrophy distribution in advanced Parkinson's disease: What makes the difference in “cognitive status” converters?
Sign Up to like & getrecommendations! Published in 2019 at "Human Brain Mapping"
DOI: 10.1002/hbm.24884
Abstract: We investigated the brain atrophy distribution pattern and rate of regional atrophy change in Parkinson's disease (PD) in association with the cognitive status to identify the morphological characteristics of conversion to mild cognitive impairment (MCI)… read more here.
Keywords: brain atrophy; cognitive status; disease; atrophy ... See more keywords