Evaluation of Safety of Stereotactic Body Radiotherapy for the Treatment of Patients With Multiple Metastases: Findings From the NRG-BR001 Phase 1 Trial.
Sign Up to like & getrecommendations! Published in 2021 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2021.0687
Abstract: Importance Stereotactic body radiotherapy (SBRT) for oligometastases is hypothesized to improve survival and is increasingly used. Little evidence supports its safe use to treat patients with multiple metastases. Objective To establish safety of SBRT dose… read more here.
Keywords: trial; treatment; sbrt; multiple metastases ... See more keywords
Validation of a method for in vivo 3D dose reconstruction in SBRT using a new transmission detector
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Applied Clinical Medical Physics"
DOI: 10.1002/acm2.12103
Abstract: Abstract Stereotactic body radiation therapy (SBRT) involves the delivery of substantially larger doses over fewer fractions than conventional therapy. Therefore, SBRT treatments will strongly benefit patients using vivo patient dose verification, because the impact of… read more here.
Keywords: system; new transmission; sbrt using; sbrt ... See more keywords
Ameliorating Mitochondrial Dysfunction of Neurons by Biomimetic Targeting Nanoparticles Mediated Mitochondrial Biogenesis to Boost the Therapy of Parkinson's Disease.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202300758
Abstract: Mitochondrial dysfunction of neurons is the core pathogenesis of incurable Parkinson's disease (PD). It is crucial to ameliorate the mitochondrial dysfunction of neurons for boosting the therapy of PD. Herein, the remarkable promotion of mitochondrial… read more here.
Keywords: mitochondrial biogenesis; parkinson disease; dysfunction neurons; mitochondrial dysfunction ... See more keywords
Dysregulation of the Retromer Complex System in Down Syndrome
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Neurology"
DOI: 10.1002/ana.25752
Abstract: Most of the patients with Down syndrome (DS) develop Alzheimer's disease (AD) neuropathology by age 40. Although this increased susceptibility to AD in DS is thought to be primarily due to triplication of the amyloid… read more here.
Keywords: dysregulation retromer; retromer complex; complex system;
Biomarkers in colorectal liver metastases
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Surgery"
DOI: 10.1002/bjs.10834
Abstract: Despite a 5‐year overall survival rate of 58 per cent after liver resection for colorectal liver metastases (CLMs), more than half of patients develop recurrence, highlighting the need for accurate risk stratification and prognostication. Traditional… read more here.
Keywords: liver metastases; biomarkers colorectal; colorectal liver; liver ... See more keywords
Geometry‐derived statistical significance: A probabilistic framework for detecting true positive findings in MRI data
Sign Up to like & getrecommendations! Published in 2023 at "Brain and Behavior"
DOI: 10.1002/brb3.2865
Abstract: The false discovery rate (FDR) procedure does not incorporate the geometry of the random field and requires high statistical power at each voxel, a requirement not satisfied by the limited number of participants in imaging… read more here.
Keywords: statistical significance; probabilistic framework; geometry; significance probabilistic ... See more keywords
Yeast surface display of full‐length human microtubule‐associated protein tau
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology Progress"
DOI: 10.1002/btpr.2920
Abstract: Microtubule‐associated protein tau is an intrinsically disordered, highly soluble protein found primarily in neurons. Under normal conditions, tau regulates the stability of axonal microtubules and intracellular vesicle transport. However, in patients of neurodegeneration such as… read more here.
Keywords: protein; associated protein; tau; microtubule associated ... See more keywords
Genetic bases of language control in bilinguals: Evidence from an EEG study
Sign Up to like & getrecommendations! Published in 2023 at "Human Brain Mapping"
DOI: 10.1002/hbm.26301
Abstract: Previous studies have debated whether the ability for bilinguals to mentally control their languages is a consequence of their experiences switching between languages or whether it is a specific, yet highly‐adaptive, cognitive ability. The current… read more here.
Keywords: 113 fdr; neural coding; language control; language ... See more keywords
Reply to "prospective study of stereotactic body radiation therapy for hepatocellular carcinoma on waitlist for liver transplant".
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32379
Abstract: We appreciate the interests and comments by Sahai et al. The median dose of stereotactic body radiation therapy (SBRT) of our patients was 50 Gy (range 30– 50 Gy).[1] In addition, the maximum dose of… read more here.
Keywords: stereotactic body; radiation therapy; radiation; study ... See more keywords
In silico structure evaluation of BAG3 and elucidating its association with bacterial infections through protein-protein and host-pathogen interaction analysis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cellular biochemistry"
DOI: 10.1002/jcb.29953
Abstract: BAG3, a co-chaperone protein with a Bcl-2-associated athanogene (BAG) domain, has diverse functionalities in protein-folding, apoptosis, inflammation, and cell cycle regulatory cross-talks. It has been well characterised in cardiac diseases, cancers, and viral pathogenesis. The… read more here.
Keywords: analysis; protein protein; structure; host ... See more keywords
Host phenotype is associated with reduced survival independent of tumour biology in patients with colorectal liver metastases
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.12358
Abstract: Most prognostic scoring systems for colorectal liver metastases (CRLMs) account for factors related to tumour biology. Little is known about the effects of the host phenotype to the tumour. Our objective was to delineate the… read more here.
Keywords: tumour biology; colorectal liver; host phenotype; biology ... See more keywords