Ameliorating Mitochondrial Dysfunction of Neurons by Biomimetic Targeting Nanoparticles Mediated Mitochondrial Biogenesis to Boost the Therapy of Parkinson's Disease.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202300758
Abstract: Mitochondrial dysfunction of neurons is the core pathogenesis of incurable Parkinson's disease (PD). It is crucial to ameliorate the mitochondrial dysfunction of neurons for boosting the therapy of PD. Herein, the remarkable promotion of mitochondrial… read more here.
Keywords: mitochondrial biogenesis; parkinson disease; dysfunction neurons; mitochondrial dysfunction ... See more keywords
Just‐in‐time clinical video review improves successful placement of Sengstaken‐Blakemore tube by emergency medicine resident physicians: A randomized control simulation‐based study
Sign Up to like & getrecommendations! Published in 2021 at "AEM Education and Training"
DOI: 10.1002/aet2.10573
Abstract: Successful completion of life‐saving procedures may benefit from a concise just‐in‐time (JIT) intervention. Video is an optimal medium for JIT training, but currently available video‐based references are not optimized for a JIT format, especially in… read more here.
Keywords: video review; medicine; video; blakemore tube ... See more keywords
Bioinformatic profiling identifies a platinum‐resistant–related risk signature for ovarian cancer
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.2692
Abstract: Most high‐grade serous ovarian cancer (HGSOC) patients develop resistance to platinum‐based chemotherapy and recur. Many biomarkers related to the survival and prognosis of drug‐resistant patients have been delved by mining databases; however, the prediction effect… read more here.
Keywords: risk; risk score; resistance; signature ... See more keywords
Spatial cytotoxic and memory T cells in tumor predict superior survival outcomes in patients with high‐grade serous ovarian cancer
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DOI: 10.1002/cam4.3942
Abstract: Although the association between tumor‐infiltrating CD3+ T and CD8+ T cells and superior survival in high‐grade serous ovarian cancer (HGSOC) has been observed, the different spatial localization of tumor‐infiltrating lymphocytes (TILs) possesses heterogeneous effects. We… read more here.
Keywords: grade serous; cd8; high grade; cancer ... See more keywords
Molecular and phenotypic characteristics influencing the degree of cytoreduction in high-grade serous ovarian carcinomas.
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DOI: 10.1002/cam4.6085
Abstract: BACKGROUND High-grade serous ovarian carcinoma (HGSOC) is the deadliest ovarian cancer subtype, and survival relates to initial cytoreductive surgical treatment. The existing tools for surgical outcome prediction remain inadequate for anticipating the outcomes of the… read more here.
Keywords: high grade; grade serous; hgsoc; serous ovarian ... See more keywords
Chaperone‐mediated autophagy attenuates H2O2‐induced cardiomyocyte apoptosis by targeting poly (ADP‐ribose) polymerase 1 (PARP1) for lysosomal degradation
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11871
Abstract: Poly (ADP‐ribose) polymerase 1 (PARP1) is a typical representative of the PARP enzyme family and is mainly related to DNA repair, gene transcription regulation, inflammation, and oxidative stress. Studies have found that PARP1 is involved… read more here.
Keywords: apoptosis; cma; parp1; degradation ... See more keywords
Monitoring the extracellular matrix remodeling of high-grade serous ovarian cancer with nonlinear optical microscopy.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of biophotonics"
DOI: 10.1002/jbio.202000498
Abstract: The mortality of high-grade serous ovarian cancer (HGSOC) accounts for 70%-80% of all ovarian cancer deaths and overall mortality rate has not declined in the last decade . Recently, many studies have demonstrated that HGSOC… read more here.
Keywords: serous ovarian; grade serous; high grade; microscopy ... See more keywords
Integrative prognostic subtype discovery in high‐grade serous ovarian cancer
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DOI: 10.1002/jcb.29049
Abstract: We sought to identify novel molecular subtypes of high‐grade serous ovarian cancer (HGSC) by the integration of gene expression and proteomics data and to find the underlying biological characteristics of ovarian cancer to improve the… read more here.
Keywords: serous ovarian; grade serous; high grade; ovarian cancer ... See more keywords
Differential histone deacetylase inhibitor-induced perturbations of the global proteome landscape in the setting of high-grade serous ovarian cancer
Sign Up to like & getrecommendations! Published in 2022 at "Proteomics"
DOI: 10.1002/pmic.202100372
Abstract: High‐grade serous ovarian cancer (HGSOC) is the most lethal gynecologic malignancy in women. Its low survival rate is attributed to late detection, relapse, and drug resistance. The lack of effective second‐line therapeutics remains a significant… read more here.
Keywords: high grade; grade serous; ovarian cancer; hgsoc ... See more keywords
Strategic concepts as micro-level tools in strategic sensemaking
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DOI: 10.1002/smj.2924
Abstract: Research Summary: The purpose of this article is to illuminate the role of concepts in strategic sensemaking. Based on a longitudinal real‐time study of a city organization, we demonstrate how the concept of “self‐responsibility” played… read more here.
Keywords: concepts micro; strategic sensemaking; micro level; organization ... See more keywords
Comorbidities, biomarkers and cause specific mortality in patients with irritable bowel syndrome: A phenome-wide association study.
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DOI: 10.1002/ueg2.12397
Abstract: BACKGROUND Irritable bowel syndrome (IBS) is one of the most common functional digestive disorders. Our understanding about its comorbidities, biomarkers, or long-term risks is still incomplete. OBJECTIVE To characterize comorbidities and biomarkers for IBS and… read more here.
Keywords: mortality; ibs patients; association study; comorbidities biomarkers ... See more keywords