MiR‐17‐3p inhibits osteoblast differentiation by downregulating Sox6 expression
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DOI: 10.1002/2211-5463.12979
Abstract: Osteoporosis and osteoarthritis are orthopedic disorders that affect millions of elderly people worldwide; stimulation of bone formation is a potential therapeutic strategy for the treatment of these conditions. As the only bone‐forming cells, osteoblasts play… read more here.
Keywords: mir; differentiation; role; osteoblast differentiation ... See more keywords
A Specific Groove Pattern Can Effectively Induce Osteoblast Differentiation
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DOI: 10.1002/adfm.201703569
Abstract: Little is known about the principles of surface structure design for orthopedic and dental implants. To find topographical groove patterns that could enhance osteoblast differentiation according to cell type, groove patterns are fabricated with ridges… read more here.
Keywords: osteoblast differentiation; groove pattern; differentiation; groove patterns ... See more keywords
Corrigendum: Strain uses gap junctions to reverse stimulation of osteoblast proliferation by osteocytes
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DOI: 10.1002/cbf.3268
Abstract: Biotechnology and Biological Sciences Research Council BB/I014608/1, Arthritis Research UK 20413, 20581, 20039. read more here.
Keywords: gap junctions; corrigendum strain; uses gap; strain uses ... See more keywords
Zoledronate promotes osteoblast differentiation in high‐glucose conditions via the p38MAPK pathway
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DOI: 10.1002/cbin.11921
Abstract: Zoledronate (ZOL) were found to inhibit bone resorption in an animal model of diabetes, high glucose concentrations have been shown to decreased the osteogenesis‐related gene expression. But the molecular mechanism by which high glucose levels… read more here.
Keywords: expression; high glucose; differentiation; osteoblast differentiation ... See more keywords
mTORC1 Inhibits NF‐κB/NFATc1 Signaling and Prevents Osteoclast Precursor Differentiation, In Vitro and In Mice
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DOI: 10.1002/jbmr.3172
Abstract: The mechanistic target of rapamycin complex 1 (mTORC1) is a critical sensor for bone homeostasis and bone formation; however, the role of mTORC1 in osteoclast development and the underlying mechanisms have not yet been fully… read more here.
Keywords: mtorc1 osteoclast; mtorc1; bone; differentiation vitro ... See more keywords
Hop2 Interacts with ATF4 to Promote Osteoblast Differentiation
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DOI: 10.1002/jbmr.3857
Abstract: Activating transcription factor 4 (ATF4) is a member of the basic leucine zipper (bZip) transcription factor family required for the terminal differentiation of osteoblasts. Despite its critical importance as one of the three main osteoblast… read more here.
Keywords: transcription; hop2; differentiation; mice ... See more keywords
Osteoblast Lineage Support of Hematopoiesis in Health and Disease
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DOI: 10.1002/jbmr.4678
Abstract: In mammals, hematopoiesis migrates to the bone marrow during embryogenesis coincident with the appearance of mineralized bone, where hematopoietic stem cells (HSCs) and their progeny are maintained by the surrounding microenvironment or niche, and sustain… read more here.
Keywords: health disease; hematopoiesis health; hematopoiesis; osteoblast lineage ... See more keywords
Intracellular density is a novel indicator of differentiation stages of murine osteoblast lineage cells.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cellular biochemistry"
DOI: 10.1002/jcb.30135
Abstract: Osteoblasts are primary bone-making cells originating from mesenchymal stem cells (MSCs) in the bone marrow. The differentiation of MSCs to mature osteoblasts involves an intermediate stage called preosteoblasts, but the details of this process remain… read more here.
Keywords: density; osteoblast lineage; lineage cells; differentiation ... See more keywords
TRIM33 is essential for osteoblast proliferation and differentiation via BMP pathway
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DOI: 10.1002/jcp.25769
Abstract: Tripartite motif containing 33 (TRIM33) functions both as a positive and negative regulator of the TGF‐β/BMP pathway in tumors; however, its effect and mechanism during osteoblast proliferation and differentiation, which involves the TGF‐β/BMP pathway is… read more here.
Keywords: osteoblast proliferation; trim33; differentiation; bmp pathway ... See more keywords
MicroRNA‐224 suppresses osteoblast differentiation by inhibiting SMAD4
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DOI: 10.1002/jcp.26596
Abstract: Osteoblast differentiation was found to be regulated by a variety of cell signaling and intracellular regulatory factors. In this study, we aimed at investigating the regulatory effect of microRNA‐224 on osteoblast differentiation and its molecular… read more here.
Keywords: mir 224; microrna 224; differentiation; osteoblast differentiation ... See more keywords
Hydrogen sulfide attenuates homocysteine‐induced osteoblast dysfunction by inhibiting mitochondrial toxicity
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DOI: 10.1002/jcp.28498
Abstract: Homocysteine (Hcy) is detrimental to bone health in a mouse model of diet‐induced hyperhomocysteinemia (HHcy). However, little is known about Hcy‐mediated osteoblast dysfunction via mitochondrial oxidative damage. Hydrogen sulfide (H2S) has potent antioxidant, anti‐inflammatory, and… read more here.
Keywords: hcy; dysfunction; mitochondrial toxicity; osteoblast dysfunction ... See more keywords