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Clinical Question Is the use of ivermectin in patients infested with scabies associated with improved clinical and safety outcomes compared with permethrin? Bottom Line Both ivermectin and permethrin treatment were… Click to show full abstract
Clinical Question Is the use of ivermectin in patients infested with scabies associated with improved clinical and safety outcomes compared with permethrin? Bottom Line Both ivermectin and permethrin treatment were associated with high clearance rates. There is low-certainty evidence that ivermectin was associated with slightly lower rates of complete clearance after 1 week compared with permethrin, 5%, cream (relative risk [RR], 0.65; 95% CI, 0.54-0.78). After 2 weeks, there was no difference in efficacy (RR, 0.91; 95% CI, 0.76-1.08; low-certainty evidence), or in the number of participants with adverse events (week 4: RR, 1.30; 95% CI, 0.35-4.83; low-certainty evidence).
Journal Title: JAMA dermatology
Year Published: 2019
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