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Systemic Immunomodulatory Treatments for Patients With Atopic Dermatitis

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Key Points Question What is the relative effectiveness of systemic treatments for patients with atopic dermatitis? Findings This network meta-analysis of 39 randomized clinical trials including 6360 patients found that… Click to show full abstract

Key Points Question What is the relative effectiveness of systemic treatments for patients with atopic dermatitis? Findings This network meta-analysis of 39 randomized clinical trials including 6360 patients found that dupilumab and cyclosporine were similarly effective for adult patients with atopic dermatitis for up to 16 weeks of treatment and were more effective than methotrexate and azathioprine. Meaning Cyclosporine and dupilumab may have better short-term effectiveness than methotrexate and azathioprine for patients with atopic dermatitis; this analysis will be updated to add evidence as new medications are approved.

Keywords: systemic immunomodulatory; dermatology; immunomodulatory treatments; atopic dermatitis; treatments patients; patients atopic

Journal Title: JAMA Dermatology
Year Published: 2020

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