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Evaluation of Potencies of Immune Globulin Products Against Hepatitis A Passive immunization with human immune globulin (IG) is recommended for prophylaxis against hepatitis A and infection with its causative agent,… Click to show full abstract
Evaluation of Potencies of Immune Globulin Products Against Hepatitis A Passive immunization with human immune globulin (IG) is recommended for prophylaxis against hepatitis A and infection with its causative agent, hepatitis A virus (HAV). Immune globulin preparations administered intramuscularly (0.02 mL/ kg) may confer protection for up to 3 months.1 Because antiHAV antibody levels are declining in plasma donors from developed countries,2 we evaluated antibody levels in currently marketed IG products. Several products had lower-than-expected anti-HAV potencies, potentially conferring protection of reduced magnitude or duration against hepatitis A.
Journal Title: JAMA Internal Medicine
Year Published: 2017
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