LAUSR

Key Points Question Are weight loss interventions associated with changes in biomarkers of liver disease in people with nonalcoholic fatty liver disease? Findings In this systematic review and meta-analysis of 22 randomized clinical trials with 2588 participants with nonalcoholic fatty liver disease, weight loss interventions were associated with clinically meaningful improvements in biomarkers of liver disease, although no evidence of changes in fibrosis was found. Meaning Evidence appeared to support changing the current clinical guidelines and recommending formal weight loss programs to treat people with nonalcoholic fatty liver disease.