LAUSR

Key Points Question What is the effect of the Lanzhou lamb rotavirus vaccination? Findings In this cross-sectional, ecological study of 33 407 patients with rotavirus gastroenteritis from 2007 to 2015 seasons in China, vaccination was associated with a 4-month increase in median age at onset and with delays in onset, peak, and cessation of incidence. The incidence rate ratio among children younger than 4 years and among children ineligible for vaccination decreased as citywide vaccination coverage increased, and the adjusted odds ratio for rotavirus gastroenteritis among unvaccinated infants decreased in areas with higher vaccination coverage. Meaning The Lanzhou lamb rotavirus vaccination can provide population health benefits in preventing rotavirus gastroenteritis, including herd effects.