LAUSR

Key Points Question Are there sex differences in genetic associations with longevity? Findings In this case-control study of 2178 cases and 2299 controls who were Chinese with Han ethnicity, sex-specific genome-wide association study and sex-specific polygenic risk score analyses on longevity showed substantial and significant differences in genetic associations with longevity between men and women. Findings indicated that previously published genome-wide association studies on longevity identified some sex-independent genetic variants but missed sex-specific longevity loci and pathways. Meaning These novel findings contribute to filling the gaps in the research literature, and further investigations may substantially contribute to individualized health care and more effective and targeted health interventions for male and female elderly individuals.