LAUSR

Key Points Question Do mothers who give birth to an infant with a major congenital anomaly have increased cardiovascular risk? Findings In this cohort study of 471 344 Danish women, mothers of infants born with a major congenital anomaly had a 15% increased risk of acute myocardial infarction, coronary revascularization, or stroke compared with women without an affected infant. This elevated risk rose to 37% among women who gave birth to more severely affected infants with multiorgan congenital anomalies. Meaning Having a child with a major congenital anomaly was associated with a small but significantly increased cardiovascular risk in the mother.