LAUSR

Key Points Question What is the association between physical activity and the risk of Parkinson disease? Findings In this systematic review and meta-analysis of more than half a million unique participants, physical activity, particularly moderate to vigorous physical activity, was associated with a significant reduction in Parkinson disease risk. This association was stronger among men than women. Meaning Physical activity may be an important protective factor for preventing the development of Parkinson disease among at-risk men; thus, large prospective studies should be performed to examine this association and to investigate the factors that underlie the observed sex difference.