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Key Points Question Do individuals with autism show atypical duration of brain functional connections? Findings In this cohort study of 52 individuals with autism and 38 typically developing participants and… Click to show full abstract
Key Points Question Do individuals with autism show atypical duration of brain functional connections? Findings In this cohort study of 52 individuals with autism and 38 typically developing participants and a replication study of 1402 participants in a brain imaging database, increased durations of functional connections in autism were found in both distributed networks and individual brain regions, which were associated with metrics of disease severity. Meaning Persistence of brain connectivity in autism may limit the ability to rapidly shift from one brain state to another and contribute to the pathophysiology of autism.
Journal Title: JAMA Network Open
Year Published: 2018
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