LAUSR

Key Points Question Are adults with a history of childhood adversity more sensitive to both positive and negative effects of environmental stressors? Findings In a longitudinal national survey of 34 458 US adults, individuals with high levels of childhood adversity demonstrated higher levels of transdiagnostic psychopathology factors associated with increased life stress and lower levels of transdiagnostic psychopathology factors associated with decreased life stress compared with individuals without childhood adversity. These associations were consistent across all transdiagnostic psychopathology domains. Meaning Childhood adversity may represent a differential susceptibility factor making individuals more vulnerable to stressors but also more sensitive to improvements in stressors.