LAUSR

Key Points Question Does regular exercise during pregnancy prevent postpartum depression? Findings In this randomized clinical trial of 639 pregnant women, individuals allocated to receive the exercise program did not have significant reductions in postpartum depression. However, noncompliance with the intervention protocol was substantial and may have resulted in underestimation of the possible benefits of the treatment (as suggested by the instrumental variable analysis). Meaning Future studies on how to promote regular exercise during pregnancy, particularly targeting young and less educated women, are warranted before further trials are undertaken.