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Key Points Question Is there an association between peripheral concentrations of the proinflammatory biomarker chemerin and incident colorectal cancer? Findings In this case-cohort study that included 221 incident colorectal cancer… Click to show full abstract
Key Points Question Is there an association between peripheral concentrations of the proinflammatory biomarker chemerin and incident colorectal cancer? Findings In this case-cohort study that included 221 incident colorectal cancer cases and 2329 cancer-free participants, higher circulating plasma chemerin concentration was associated with a greater risk of colorectal cancer. This association was independent of known risk factors for colorectal cancer, including age, adiposity, lifestyle, and metabolic factors. Meaning Chemerin could have a role as an important inflammatory agent in the development of colorectal cancer and may serve as a promising future preventive and/or therapeutic target.
Journal Title: JAMA Network Open
Year Published: 2019
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