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Key Points Question Which immunosuppressive strategy is associated with the highest survival in lung transplantation? Findings In this cohort study of US recipients of lung transplants, sirolimus plus tacrolimus was associated with… Click to show full abstract
Key Points Question Which immunosuppressive strategy is associated with the highest survival in lung transplantation? Findings In this cohort study of US recipients of lung transplants, sirolimus plus tacrolimus was associated with significantly better conditional survival from 1 year after transplant compared with mycophenolate mofetil plus tacrolimus (median survival, 8.9 vs 7.1 years after transplant). The highest conditional survival was observed in patients receiving sirolimus plus tacrolimus with no induction therapy (median survival, 10.7 years), which was significantly better than survival for those receiving mycophenolate mofetil plus tacrolimus with induction therapy (median survival, 7.4 years). Meaning Sirolimus plus tacrolimus was associated with improved patient survival compared with mycophenolate mofetil plus tacrolimus, and using no induction therapy with sirolimus plus tacrolimus was associated with the highest survival.
Journal Title: JAMA Network Open
Year Published: 2019
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