LAUSR

Key Points Question Is β-amyloid deposition in the brain associated with sleep dysfunction and cognition in elderly individuals with cognitive disorders? Findings In this survey study of 52 participants aged 65 years and older, β-amyloid deposition in the precuneus was associated with the number of nocturnal awakenings, whereas β-amyloid deposition in the brainstem was associated with daytime sleepiness. Nocturnal awakenings, but not daytime sleepiness, were associated with poor cognition, and β-amyloid deposition was indirectly associated with cognitive impairment via nocturnal awakenings. Meaning In elderly individuals with cognitive disorders, a mechanism that involves disruption of nighttime sleep may underlie the association between β-amyloid deposition and cognitive impairment.