LAUSR

Key Points Question What is the trajectory of β-amyloid accumulation over time, and how is it associated with clinical and cognitive decline among patients with probable dementia with Lewy bodies? Findings This cohort study of 175 participants found that the cumulative density of β-amyloid accumulation by time in years followed a sigmoid-shaped form among patients with probable dementia with Lewy bodies as well as among cognitively unimpaired participants who were matched by age, sex, and apolipoprotein e4 status. In dementia with Lewy bodies, both baseline and longitudinal β-amyloid load accumulation were associated with measures of clinical and cognitive decline over time. Meaning The results of this study suggest that longitudinal β-amyloid accumulation among patients with dementia with Lewy bodies could be used to track the clinical progression of dementia with Lewy bodies and potentially to design clinical trials targeting β-amyloid in dementia with Lewy bodies.